A study presented at the 31st Annual Meeting of the American Society for Bone and Mineral Research (ASBMR) found that use of some antidepressants may have a correlation with reduced bone mineral density (BMD) in women.
While data have been circulated since the late 1990s associating the use of selective serotonin reuptake inhibitors (SSRIs) with an increased risk of hip fractures, the studies have been in elderly women.
"They were based on database studies and were not able to control for important variables such as bone density and other health conditions," said Susan Diem, MD, University of Minnesota, Minneapolis, Minnesota, on September 12. "Basic science data in the last few years have also found that serotonin transcriptors may exist on bone cells. SSRIs, which block serotonin transcription, might then have an effect on bone density."
READ MORE @ DOCTOR'S GUIDE
Showing posts with label women. Show all posts
Showing posts with label women. Show all posts
Sunday, September 13, 2009
Saturday, August 8, 2009
Antidepressants once seen as miracle drugs: now risks are becoming evident
Since the horror of the Thalidomide scandal in the 1960s, pharmaceutical companies and medicines regulators have been acutely aware of the dangers drugs may pose to the unborn child.
Establishing what the effect of a drug may be on a foetus, however, is no simple task. Companies must rely on animal studies in the early stages of research and hope that the drug will behave in humans in the same way. Trials on pregnant women are rarely carried out, for obvious reasons.
Depression and anxiety became big business for the pharmaceutical industry in the 1990s as doctors became better at diagnosing the problems, exposing a population of over-achieving, highly-stressed, worried-well.
Women, always more willing to see a doctor than men, were a large proportion of those diagnosed and put on SSRIs (selective serotonin reuptake inhibitors) such as Prozac and the British drug Seroxat, known as Paxil in the US. For a while, these seemed to be the new miracle drugs. They were safer than older antidepressants because the severely depressed could not overdose on them.
But in court cases about to begin in the US, it will be argued that insufficient attention was paid to the possible dangers for young women who were pregnant or might become pregnant and more particularly, for their babies.
READ MORE @ GUARDIAN
Establishing what the effect of a drug may be on a foetus, however, is no simple task. Companies must rely on animal studies in the early stages of research and hope that the drug will behave in humans in the same way. Trials on pregnant women are rarely carried out, for obvious reasons.
Depression and anxiety became big business for the pharmaceutical industry in the 1990s as doctors became better at diagnosing the problems, exposing a population of over-achieving, highly-stressed, worried-well.
Women, always more willing to see a doctor than men, were a large proportion of those diagnosed and put on SSRIs (selective serotonin reuptake inhibitors) such as Prozac and the British drug Seroxat, known as Paxil in the US. For a while, these seemed to be the new miracle drugs. They were safer than older antidepressants because the severely depressed could not overdose on them.
But in court cases about to begin in the US, it will be argued that insufficient attention was paid to the possible dangers for young women who were pregnant or might become pregnant and more particularly, for their babies.
READ MORE @ GUARDIAN
Monday, March 16, 2009
Antidepressants Linked to Sudden Cardiac Death in Women
A new study has concluded that women with no history of cardiac problems but who use antidepressants are at an increased risk for sudden cardiac death (SCD). HealthDay ,News reports that the reason for the link remains unknown, according to the researchers whose findings were published in the Journal of the American College of Cardiology.
“We suspect that their use is a marker for people with worse depression,” explained the study’s lead author Dr. William Whang, an assistant professor of clinical medicine at Columbia University Medical Center in Manhattan. “The elevated risk seems more specific for antidepressant use, but that use may well be a marker of more severe symptoms,” quoted HealthDay News. Whang noted that the link seemed to be physiological saying, “We found that women who had worse depressive symptoms had higher rates of risk factors such as hypertension, diabetes, and smoking.” As a matter-of-fact, the report indicated, said HealthDay News, women with clinical depression were at a two-fold risk of experiencing SCD.
READ MORE @ NEWS INFERNO
“We suspect that their use is a marker for people with worse depression,” explained the study’s lead author Dr. William Whang, an assistant professor of clinical medicine at Columbia University Medical Center in Manhattan. “The elevated risk seems more specific for antidepressant use, but that use may well be a marker of more severe symptoms,” quoted HealthDay News. Whang noted that the link seemed to be physiological saying, “We found that women who had worse depressive symptoms had higher rates of risk factors such as hypertension, diabetes, and smoking.” As a matter-of-fact, the report indicated, said HealthDay News, women with clinical depression were at a two-fold risk of experiencing SCD.
READ MORE @ NEWS INFERNO
Saturday, January 31, 2009
Women's mental health deteriorates as one in five experience common disorders
An NHS report has found a significant increase in the number of women suffering from depression, anxiety and suicidal thoughts
Women's mental health is deteriorating according to an NHS report that has found that more than one in five of the adult female population experiences depression, anxiety or suicidal thoughts.
The report found the proportion of women aged 16-64 with common mental disorders (CMDs) increased from 19.1% in 1993 to 21.5% in 2007, whereas the rate in men did not alter significantly.
The largest increase in CMD rates, up 20% between 1993 and 2007, was among women aged 45-64. The proportion of women aged 16-74 reporting suicidal thoughts also increased from 4.2% in 2000 to 5.5% in 2007.
Based on the results of a study of over 7,000 households carried out by the National Centre for Social Research together with researchers at the University of Leicester, the Adult Psychiatric Morbidity Survey is the latest in a series of surveys conducted at roughly seven-year intervals, with previous surveys carried out by the Office for National Statistics in 1993 and 2000.
READ MORE @ GUARDIAN
Women's mental health is deteriorating according to an NHS report that has found that more than one in five of the adult female population experiences depression, anxiety or suicidal thoughts.
The report found the proportion of women aged 16-64 with common mental disorders (CMDs) increased from 19.1% in 1993 to 21.5% in 2007, whereas the rate in men did not alter significantly.
The largest increase in CMD rates, up 20% between 1993 and 2007, was among women aged 45-64. The proportion of women aged 16-74 reporting suicidal thoughts also increased from 4.2% in 2000 to 5.5% in 2007.
Based on the results of a study of over 7,000 households carried out by the National Centre for Social Research together with researchers at the University of Leicester, the Adult Psychiatric Morbidity Survey is the latest in a series of surveys conducted at roughly seven-year intervals, with previous surveys carried out by the Office for National Statistics in 1993 and 2000.
READ MORE @ GUARDIAN
Monday, January 12, 2009
Women-only gene link to dementia
Scientists have found a genetic risk factor for late onset Alzheimer's disease which is only carried by women.
The discovery is the first evidence to suggest that genetics may partly explain why more women than men tend to develop the disease.
The key variant was found in a gene on the X chromosome, of which females have two copies, but males only one.
The study, by the Mayo Clinic College of Medicine, features in the journal Nature Genetics.
The Mayo team carried out a detailed genetic analysis of patients with Alzheimer's diease.
They identified a particular variant of a gene called PCDH11X which appeared to be closely linked to a higher risk of the disease.
However, further analysis showed that the association was almost entirely restricted to women.
READ MORE @ BBC
The discovery is the first evidence to suggest that genetics may partly explain why more women than men tend to develop the disease.
The key variant was found in a gene on the X chromosome, of which females have two copies, but males only one.
The study, by the Mayo Clinic College of Medicine, features in the journal Nature Genetics.
The Mayo team carried out a detailed genetic analysis of patients with Alzheimer's diease.
They identified a particular variant of a gene called PCDH11X which appeared to be closely linked to a higher risk of the disease.
However, further analysis showed that the association was almost entirely restricted to women.
READ MORE @ BBC
Tuesday, January 22, 2008
Antidepressants behind 52 percent of all suicides among women
Incredible data have just been revealed that antidepressant drugs were behind 52 percent of all suicides among women (18-84) in Sweden (2006)
This is not data from a limited study; it instead concerns information on a national level for ALL suicides (18-84 years) for 2006. The information is unique; registries now exist in Sweden making it possible for the National Board of Health and Welfare to see how many of the suicides were preceded by psychiatric drug treatment.
Among a total number of 377 women who committed suicide, 197 (52%) had filled a prescription for antidepressants within 180 days before their death. And 29 women (8%) had filled a prescription for neuroleptics ("antipsychotics") ONLY within 180 days before the suicide.
This means that 229 women - 60% - of those who committed suicide (18-84) in Sweden (2006) had filled a prescription for antidepressant drugs OR neuroleptics within 180 days before their suicide.
Neuroleptics were involved in total in 97 (26%) of the suicides among women, (68 women, 18%, got BOTH antidepressants and neuroleptics). NOT included in these figures is the percentage of women who got other forms of psychiatric drugs, like benzodiazepines.
The data are revealed just after the news broke that pharmaceutical companies have systematically hidden negative and exaggerated positive results in their clinical trials of antidepressants (see article Antidepressant Studies Unpublished in NYT), thus misleading patients and doctors for many years.
READ MORE @ TRANS WORLD NEWS
This is not data from a limited study; it instead concerns information on a national level for ALL suicides (18-84 years) for 2006. The information is unique; registries now exist in Sweden making it possible for the National Board of Health and Welfare to see how many of the suicides were preceded by psychiatric drug treatment.
Among a total number of 377 women who committed suicide, 197 (52%) had filled a prescription for antidepressants within 180 days before their death. And 29 women (8%) had filled a prescription for neuroleptics ("antipsychotics") ONLY within 180 days before the suicide.
This means that 229 women - 60% - of those who committed suicide (18-84) in Sweden (2006) had filled a prescription for antidepressant drugs OR neuroleptics within 180 days before their suicide.
Neuroleptics were involved in total in 97 (26%) of the suicides among women, (68 women, 18%, got BOTH antidepressants and neuroleptics). NOT included in these figures is the percentage of women who got other forms of psychiatric drugs, like benzodiazepines.
The data are revealed just after the news broke that pharmaceutical companies have systematically hidden negative and exaggerated positive results in their clinical trials of antidepressants (see article Antidepressant Studies Unpublished in NYT), thus misleading patients and doctors for many years.
READ MORE @ TRANS WORLD NEWS
Wednesday, November 28, 2007
Hormonal Changes And Depression: What Is The Connection?
Women are more susceptible to mood disorders and depression during hormonal transitions, such as pregnancy, postpartum and perimenopause, according to a new report by the Society for Women's Health Research, a Washington, D.C.-based advocacy organization, released at a media briefing held at the Palace Hotel in New York City.
The report summarizes a June 2007 thought leaders' roundtable of eight national experts convened by the Society and the National Institute of Mental Health to discuss current efforts to understand the effects of hormonal transitions on mood disorders in women and to make recommendations for future research.
READ MORE@MEDICAL NEWS TODAY
The report summarizes a June 2007 thought leaders' roundtable of eight national experts convened by the Society and the National Institute of Mental Health to discuss current efforts to understand the effects of hormonal transitions on mood disorders in women and to make recommendations for future research.
READ MORE@MEDICAL NEWS TODAY
Tuesday, June 12, 2007
Depression + osteoporosis link still unclear
Older women who take certain antidepressants are at increased risk of fracturing a bone, but it's not clear whether the association is due to the drugs, depression itself, or some other factor, according to a new report in the Harvard Women's Health Watch.
Nevertheless, while women shouldn't stop taking antidepressant drugs for the sole reason of protecting their bones, those who suffer from depression should get their bone mineral density checked out, the report's authors state.
READ MORE @ REUTERS
Nevertheless, while women shouldn't stop taking antidepressant drugs for the sole reason of protecting their bones, those who suffer from depression should get their bone mineral density checked out, the report's authors state.
READ MORE @ REUTERS
Friday, June 1, 2007
Sildenafil Effective for SRI Associated Sexual Dysfunction
Depressed women with serotonin reuptake inhibitor (SRI) antidepressant-associated sexual dysfunction are able to continue taking effective antidepressant treatment with sildenafil while avoiding sexual side effects.
READ MORE @ DOCTOR'S GUIDE
READ MORE @ DOCTOR'S GUIDE
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