The novel antipsychotic lurasidone appears to improve acute schizophrenia symptoms without the weight gain or metabolic problems common among second generation agents, according to a preliminary report from the drug's second pivotal trial.
Patients treated with the 40 and 120 mg doses of the drug had reductions of 25.7 and 23.6 points on the Positive and Negative Syndrome Scale (PANSS) total score, significantly greater than the 16.0 decline among placebo treated patients, according to data released by drug developer Dainippon Sumitomo Pharma.
In the phase III PEARL 2 (Program to Evaluate the Antipsychotic Response to Lurasidone) trial, 53% of patients on the lower dose and 47% on the higher dose had at least a 30% improvement on symptom score from baseline whereas only 38% on placebo did.
The company press release also announced that lurasidone met key secondary efficacy endpoints at both doses in the trial, including change from baseline on the Clinical Global Impressions Severity scale (-1.5 and -1.4 versus -1.1, respectively).
The results are expected to be reported in greater detail at the American College of Neuropsychopharmacology meeting later this year.
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