Thursday, May 8, 2008

Unraveling the Link Between Genes and Environment

New studies in the field of epigenetics -- which looks at how environmental factors can change gene function without altering DNA sequence -- are identifying new molecular targets that may lead to improved drug treatment of depression, scientists report.

Epigenetics plays a major role in depression and the actions of antidepressants.

"The mechanisms that precipitate depression, such as stress, are incompletely understood," Dr. Eric Nestler, of the University of Texas Southwestern Medical School in Dallas, said in a prepared statement. "One mystery of the disease is its long-lasting nature and delayed response to antidepressant treatment. This persistence is thought to be influenced by slowly developing but stable adaptations, which might include epigenetic regulation."

Nestler held a symposium Monday on epigenetics at the American Psychiatric Association annual meeting, in Washington, D.C. A number of scientists outlined their research on epigenetics and depression. The symposium was sponsored by the U.S. National Institute of Mental Health.

READ MORE @ WASHINGTON POST