A two-pronged intervention of optimized antidepressant and behavioral pain management therapy improves symptoms of comorbid pain and depression, a randomized trial showed.
The intervention yielded a clinically and statistically significant reduction of at least 50% in depression symptoms and at least 30% in pain for three times more patients than did usual care, which was significant at both six months (23.6% versus 7.9%) and 12 months (26.0% versus 7.9%).
The number needed to treat to improve pain to this threshold was 4.1, and it was 4.8 to achieve a response for depression, Kurt Kroenke, M.D., of Indiana University in Indianapolis, and colleagues reported in the May 27 issue of the Journal of the American Medical Association.
This was similar to the number needed to treat of 4 in a Cochrane review of antidepressants compared with placebo or no treatment in medically ill adults, they noted.
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